Big Sis Resigns Amid Sex Scandal (VIDEO)

Janet Napolitano, also know as Big Sis, will resign as boss of the Department of Homeland Security. She will seek the post as president of the University of California, according to media reports.

Napolitano's departure is scheduled for September.

"For more than four years I have had the privilege of serving President Obama and his Administration as the Secretary of Homeland Security," she said in a statement. "The opportunity to work with the dedicated men and women of the Department of Homeland Security, who serve on the frontlines of our nation's efforts to protect our communities and families from harm, has been the highlight of my professional career. We have worked together to minimize threats of all kinds to the American public."

She said "I know the Department of Homeland Security will continue to perform its important duties with the honor and focus that the American public expects."

Obama issued a statement commending Napolitano for "her outstanding work on behalf of the American people over the last four years."